NEET Biology
Molecular Basis of Inheritance
Question 1:
The bond that joins two nucleotides in a DNA strand is:[Level: Moderate]
(a)glycosidic bond
(b)phosphoester bond
(c)phosphodiester bond
(d)hydrogen bonds
Question 2:
The methodology of Sequence Annotation used in Human Genome Project includes sequencing: [Level: Moderate]
(a)only those gene which are expressed as RNAs
(b)only the non-coding genes
(c)both coding and non-coding regions of the genome
(d)repetitive sequences in the DNA.
Question 3:
The percentage composition of guanine in a double stranded DNA is 30%. Find the percentage composition of other nitrogenous bases.[Level: Moderate]
(a)[A] = 20%, [C] = 20%, [T] = 30%
(b)[A] = 30%, [C] = 20%, [T] = 30%
(c)[A] = 20%, [C] = 30%, [T] = 20%
(d)[A] = 30%, [C] = 30%, [T] = 20%
Question 4:
The biochemical nature of the transforming principle was determined by:[Level: Easy]
(a)Griffith
(b)Avery, MacLeod and McCarty
(c)Hershey and Chase
(d)Meselson and Stahl
Question 5:
The Okazaki fragments of lagging strand are joined due to the activity of enzyme:[Level: Easy]
(a)DNA polymerase
(b)DNA ligase
(c)DNA
(d)Primase
Question 6:
Which among the following statements regarding transcription is incorrect?[Level: Difficult]
(a) Transcription begins when sigma factor binds transiently with the RNA polymerase.
(b)RNA polymerase I transcribes hnRNA, the precursor of mRNA in eukaryotes.
(c)RNA polymerase III helps in the transcription of 5S rRNA, tRNA and snRNA.
(d)The termination of transcription occurs when rho factor binds to the RNA polymerase in the terminator region of the transcription unit.
Question 7:
In eukaryotes, the precursor of mRNA is synthesised by:[Level: Moderate]
(a)RNA polymerase I only
(b)RNA polymerase II only
(c)RNA polymerase I and III
(d)RNA polymerase III only
Question 8:
Some viruses can direct the synthesis of DNA from RNA. This process is called:[Level: Moderate]
(a)transcription
(b)replication
(c)translation
(d)reverse transcription
Question 9:
In a transcription unit, the terminator is located at:[Level: Easy]
(a)5’ end of template strand
(b)3’ end of template strand
(c)5’ end of coding strand
(d)3’ end of coding strand
Question 10:
Read the statements given below:[Level: Difficult]
I. rRNA serves as a template for protein synthesis.
II. tRNA brings amino acids to the site of protein synthesis and reads the genetic code.
III. RNA polymerase binds to the promoter region and initiates translation.
IV. A segment of DNA coding for protein is called intron.
In the light of above statements, choose the set of statements which are correct.
(a)I and III only
(b)II and III only
(c)Only II
(d)Only IV
Question 11:
Given below is a sequence of nucleotides on the mRNA. Using the sequence, how many amino acids can be polymerised during translation to form a polypeptide chain?[Level: Moderate]
5’ – AUGGUGCCUGGUGGGUUUUCGUUAUGACCA – 3’
(a)7
(b)8
(c)9
(d)10
Question 12:
The feature of genetic code that indicates that one amino acid can be coded by more than one codon is:[Level: Moderate]
(a)degeneracy
(b)universality
(c)non-ambiguity
(d)collinearity
Question 13:
Read the following statements:[Level: Difficult]
I. DNA mutates at a faster rate than RNA.
II. The 2’-OH group of RNA makes it more labile and easily degradable
III. Transcription and translation in prokaryotes can be coupled as they take place in same compartment.
IV. RNA is a better genetic material for the storage of genetic information.
V. Both DNA and RNA can direct their synthesis due to complementarity of their base pairs.
In the light of above statements, find the set of correct statements from the options given below:
(a) I and III only
(b) II, III and V
(c) II, III, IV and V
(d) I, II, III and IV
Question 14:
The process of removal of introns during post-transcriptional modifications in eukaryotes is called:[Level: Moderate]
(a)Capping
(b)Splicing
(c)Tailing
(d)Initiation
Question 15:
In an mRNA molecule, the untranslated regions are present:[Level: Moderate]
(a) before the start codon
(b) after the start codon
(c) after stop codon
(d) before start codon and after stop codon
Question 16:
Statement I:[Level: Difficult]
Three codons – UAA, UAG and UGG do not code for any amino acid.
Statement II:
AUG has dual functions – codes for methionine and acts a start codon.
With respect to the statements given above, choose the correct answer from the options given below:
(a) Statement I is correct but Statement II is incorrect.
(b) Statement I is incorrect but Statement II is correct.
(c) Both Statement I and Statement II are incorrect.
(d) Both Statement I and Statement II are correct.
Question 17:
Match the items given in Column I to Column II and find the correct answer from the options given below: [Level: Difficult]
Column I |
Column II |
|||||
1. Site of attachment of RNA polymerase |
(i) operator gene |
|||||
2. Transcribes mRNA for protein synthesis |
(ii) structural gene |
|||||
3. Controls the activity of operator gene |
(iii) promoter gene |
|||||
4. Interacts with repressor protein |
(iv) regulator gene |
|||||
|
1. |
2. |
3. |
4. |
|
|
(a) |
(iii) |
(ii) |
(iv) |
(i) |
|
|
(b) |
(ii) |
(iii) |
(iv) |
(i) |
|
|
(c) |
(iii) |
(ii) |
(i) |
(iv) |
|
|
(d) |
(ii) |
(iii) |
(iv) |
(i) |
|
|
Question 18:
The last of the 24 chromosomes to be sequenced under Human Genome Project was:[Level: Moderate]
(a)chromosome 1
(b)chromosome 16
(c)chromosome 11
(d)chromosome 17
Question 19:
The enzyme β-galactosidase in lac operonis coded by: [Level: Easy]
(a)i-gene
(b)y-gene
(c)a-gene
(d)z-gene
Question 20:
The experimental proof for semi-conservative mode of DNA replication was shown in bacterium E.coli by: [Level: Easy]
(a) Sutton and Boveri
(b) Watson and Crick
(c) Meselson and Stahl
(d) Hershey and Chase
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