The centre for control of respiration is present in the medulla region of the brain, which is primarily responsible for the regulation of respiration. The pneumotaxic centre can alter the function performed by the respiratory rhythm centre by signalling to reduce the inspiration rate.

There is a chemosensitive region present near the respiratory centre which is sensitive to carbon dioxide and hydrogen ions. This region then signals to change the rate of expiration for eliminating the compounds.

Another regulation is carried on by the receptors present in the carotid artery and aorta, wwhich can detect the levels of carbon dioxide and hydrogen ions in blood. As the level of carbon dioxide increases, the respiratory centre sends nerve impulses for the necessary changes.